Myelin-axon interface vulnerability in Alzheimer's disease revealed by subcellular proteomics and imaging of human and mouse brain.

Yifei Cai, Iguaracy Pinheiro-de-Sousa, Mykhaylo Slobodyanyuk, Fuyi Chen, Tram Huynh, Jean Kanyo, Peiyang Tang, Lukas A. Fuentes, Amber Braker, Rachel Welch, A. Huttner, Lei Tong, Peng Yuan, Tukiet Lam, E. Petsalaki, J. Reimand, AC Nairn, J. Grutzendler

Nature Neuroscience, 2025

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease

Yifei Cai, Jean Kanyo, Rashaun Wilson, S. Bathla, P. L. Cardozo, Lei Tong, Shanshan Qin, Lukas A. Fuentes, Iguaracy Pinheiro-de-Sousa, Tram Huynh, Liyuan Sun, M. Mansuri, Zichen Tian, Hao-Ran Gan, Amber Braker, Hoang Kim Trinh, A. Huttner, Tukiet Lam, E. Petsalaki, Kristen J. Brennand, AC Nairn, J. Grutzendler

Nature Aging, 2025