Publications


Axonal and myelin pathology in Alzheimer's disease


Myelin-axon interface vulnerability in Alzheimer's disease revealed by subcellular proteomics and imaging of human and mouse brain.


Yifei Cai, Iguaracy Pinheiro-de-Sousa, Mykhaylo Slobodyanyuk, Fuyi Chen, Tram Huynh, Jean Kanyo, Peiyang Tang, Lukas A. Fuentes, Amber Braker, Rachel Welch, A. Huttner, Lei Tong, Peng Yuan, Tukiet Lam, E. Petsalaki, J. Reimand, AC Nairn, J. Grutzendler

Nature Neuroscience, 2025


Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease


Yifei Cai, Jean Kanyo, Rashaun Wilson, S. Bathla, P. L. Cardozo, Lei Tong, Shanshan Qin, Lukas A. Fuentes, Iguaracy Pinheiro-de-Sousa, Tram Huynh, Liyuan Sun, M. Mansuri, Zichen Tian, Hao-Ran Gan, Amber Braker, Hoang Kim Trinh, A. Huttner, Tukiet Lam, E. Petsalaki, Kristen J. Brennand, AC Nairn, J. Grutzendler

Nature Aging, 2025


PLD3 affects axonal spheroids and network defects in Alzheimer’s disease


Peng Yuan, Mengyang Zhang, Lei Tong, Thomas M Morse, Robert A McDougal, Hui Ding, Diane Chan, Yifei Cai, Jaime Grutzendler

Nature, 2022, pp. 1-10


Spatial proteomics and iPSC modeling uncover mechanisms of axonal pathology in Alzheimer's disease


Yifei Cai, Jean Kanyo, Raushan Wilson, Mohammad Shahid Mansuri, Pablo Leal Cardozo, Derek Goshay, Zichen Tian, Amber Braker, Hoang Kim Trinh, TuKiet Lam, Kristen Brennand, Angus C. Nairn, Jaime Grutzendler

bioRxiv, 2022


Non-coding RNA regulation in Alzheimer's disease


MiR-409-5p as a regulator of neurite growth is down regulated in APP/PS1 murine model of Alzheimer's disease


Jing Guo, Yifei Cai, Xiaoyang Ye, Nana Ma, Yuan Wang, Bo Yu, Jun Wan

Frontiers in Neuroscience, vol. 13, 2019, p. 1264


Competing endogenous RNA regulations in neurodegenerative disorders: current challenges and emerging insights


Yifei Cai, Jun Wan

Frontiers in Molecular Neuroscience, vol. 11, 2018, p. 370


Rpph1 upregulates CDC42 expression and promotes hippocampal neuron dendritic spine formation by competing with miR-330-5p


Yifei Cai, Ziling Sun, Huizhen Jia, Hongxue Luo, Xiaoyang Ye, Qi Wu, Yi Xiong, Wei Zhang, Jun Wan

Frontiers in molecular neuroscience, vol. 10, 2017, p. 27


Neurogenetics in psychiatric disorders


Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice


Jun Mukai, Enrico Cannavò, Gregg W Crabtree, Ziyi Sun, Anastasia Diamantopoulou, Pratibha Thakur, Chia-Yuan Chang, Yifei Cai, Stavros Lomvardas, Atsushi Takata, Bin Xu, Joseph A Gogos

Neuron, vol. 104(3), 2019, pp. 471-487. e12


Genetics in adverse drug events


Augmenting LASSO regression with decision tree for identifying the correlation of genetic polymorphism and adverse events


Yi-fei Cai, Zhao-hui Liang, Tong He, Gang Zhang, Jimmy Xiangji Huang, Xing Zeng

2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE, 2013, pp. 355-360

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